How to report an unexpected adverse side effect
Come segnalare una reazione avversa di un farmaco
Allergies are an abnormal and specific reaction of the immune system and with regard to substances foreign to the body, the allergens. The allergens can be of various kinds: pollen, dust, mold, food, occupational agents, mites, insect venom, animal fur. In allergic subjects, allergens induce the production of antibodies of the IgE type that, during exposure to allergens, causing the release of various substances by certain immune system cells, mast cells and basophils. The main substance released during exposure to the allergens is histamine. It induces an excessive reaction of the blood vessels and smooth muscle tissue and then the appearance of allergic symptoms that varies depending on the part of the body involved. Allergies have a major impact on the general well-being of subjects because reduce the working capacity, quality of life, the ability of learning and performing normal daily activities.
Allergic Rhinoconjunctivitis is a disorder caused by the release of histamine in the nasal mucosa after exposure to inhaled allergens (pollen, dust, etc.). It occurs with nasal symptoms (runny nose, sneezing, obstruction, itching) and ocular symptoms (redness, itching, burning, watery eyes). These symptoms negatively affect the quality of sleep, induce fatigue, headache, irritability. Many patients with allergic rhinoconjunctivitis also suffer from bronchial asthma.
Urticaria is characterized by the sudden appearance of wheals, that consists of a swelling area on the skin, reddish with a lighter central area, ranging in size and very itchy, generally lasting for less than 24. In the case of urticaria the release of histamine in the skin can be induced by allergens or by drugs, contrast media, foods, animal poisons, physical stimuli (pressure, cold, heat).